Liza Velarde • Co Founder, Director & CEO
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Alejandro Abarca • Co Founder, Director & CTO
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Juan Felipe Yee • Co Founder, Director & CMO
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*Images used in this photo are in the prototype phase, CytoCatch is not currently available on the market.
Since our last raise
*Images used in this photo are in the prototype phase, CytoCatch is not currently available on the market.
The Problem
* Source
Cancer has become a major global health issue. According to the International Agency for Research on Cancer (IARC), in 2020, the number of new registered cases surpassed 19.2 M globally, whereas over 9.9 M deaths occurred due to this disease (Source). Despite all the recent breakthroughs in cancer treatments, it is estimated that by 2040, the number of new registered cases and fatalities per year will increase to 30.2 M and 16.3 M, respectively (Source, Source). The National Cancer Institute (NCI) estimates that 39.5% of Americans will be diagnosed with cancer at some point during their lifetime (Source), unfortunately, many of these people will lose their lives because of it. One of the main reasons cancer has such a high mortality rate is due to the current lack of tests with the required sensitivity and specificity to enable an early diagnosis of the disease.
When it comes to cancer, the detection of tumors at an early stage is key because the survival rate in most types of cancer is directly related to the stage at which tumors are detected. For example, the 5-year relative survival rate for breast cancer when detected at early stages is 99%, but drops to 28% when detected at late stages (Source). Furthermore, early detection has the potential to reduce the financial burden of health care on individuals and public health services mainly because cancer treatments used for treating localized disease are less complex, and therefore, less expensive; according to the World Health Organization (WHO), studies made in high-income countries have shown that the cost of cancer treatment, when detected at early stages, is 2 to 4 times less expensive than at advanced stages (Source).
Moreover, there is a lack of technological resources to provide effective monitoring of the applied cancer treatments’ efficacy, which may significantly reduce the patients’ chances of survival given that the right treatment at the right time for each cancer patient may not be administered due to the lack of information available for physicians.
Since there is an unmet need for tests that can reliably detect cancer at early stages and monitor the applied treatments’ effectiveness, the research community has been actively searching for novel biomarkers that can provide clinical information for these purposes. The isolation of circulating tumor cells (CTCs) from blood is a recent alternative that could address this need. In the last decade, CTCs have attracted a significant amount of attention for their potential use as a blood-based biomarker for a broad range of cancer-related clinical applications. CTCs are malignant cells that are shed from the primary and/or metastatic solid tumors that infiltrate into the vascular and lymphatic systems; these cells play a fundamental role in the metastatic process of non-hematological cancers (Source, Source).
Technologies that detect and isolate CTCs from blood can be used to develop assays that could enable early cancer detection and monitor the applied treatments’ effectiveness. However, the isolation of these malignant cells from blood represents a major technological challenge due to their heterogeneity and extremely low numbers in comparison to blood cells (Source, Source); on average, you can find around 40.5 billion cells in 7.5 mL of blood, while a cancer patient may have between 1 and 1000 CTCs in the same volume (Source).
Even though there currently exists multiple cell sorting methods, such as fluorescent-activated cell sorting, magnetic-activated cell sorting, fluorescent-activated droplet sorting, and density gradient centrifugation, these are not compatible with whole blood samples and/or do not have the sufficient sensitivity and specificity to correctly isolate CTCs from blood, which have prevented the development of assays with potential clinical utility... until now.
Our Solution
At Delee, we have created the CytoCatch™ isolation platform and imaging system. These units enable the performance of a CTC blood-based assay that has the potential of being used for early cancer detection and monitoring of the applied treatments’ effectiveness, allowing the optimization of each patient’s therapy throughout the course of the disease.
*Images used in this photo are in the prototype phase, CytoCatch is not currently available on the market.
How it works
For the assay, a single blood tube is extracted by conventional venipuncture (the collection method that is usually used for laboratory testing). The blood sample along with several reagents are loaded on the CytoCatch™ isolation platform, which automatically performs the necessary steps to prepare and process the sample, capturing the contained CTCs. The unit has an outstanding performance, it has recovery rates above 94% when processing 7.5 mL blood samples spiked with tumor cells from prostate, breast, and colorectal cancer cell lines, meaning that the platform recovers at least 94 out of 100 tumor cells spiked into the sample (Source).
Once captured, the CytoCatch™ isolation platform executes an automated protocol to stain the collected cells with fluorescent antibodies for their further analysis with the CytoCatch™ imaging system, which possesses special routines and machine learning algorithms that analyze the captured cells based on their morphology and the expression of specific markers. The fact that all these processes are fully automated increases the reliability and reproducibility of the assay by preventing human error and cell loss due to manual steps.
Furthermore, the collected cells are compatible with traditional molecular biology techniques and next generation sequencing technologies, enabling the performance of molecular analyses to assess the genetic characteristics of the captured CTCs. Finally, the treating physician will get a report with the corresponding results.
*Images used in this photo are in the prototype phase, CytoCatch is not currently available on the market.
ONCOLOGICAL CLINICAL APPLICATIONS
*Images used in this photo are in the prototype phase, CytoCatch is not currently available on the market.
BENEFITS OF OUR TECHNOLOGY
FOR WHAT TYPES OF CANCER?
Traction
We’ve gotten great traction since the pre-commercial launch of our technology. To date, pre-orders worth a potential value of over $2.5 million USD have been secured from research centers of various hospitals in order to use our technology as an in vitro diagnostic platform for research use only, prior to FDA clearance.
Customers
Business Model
*Images used in this photo are in the prototype phase, CytoCatch is not currently available on the market.
Market
At Delee, we are initially validating our technology for prostate and breast cancer, to later expand it to lung and colorectal cancer, mainly because, in 2020 alone, these four types of cancer account for over 40% of the new cancer cases registered worldwide and were responsible for over 3.7 million deaths (Source).
Competitors
Most of the blood tests employed as auxiliaries in the diagnosis of cancer and monitoring of the applied treatments’ effectiveness measure protein tumor markers levels, such as PSA, CA-125, and AFP. However, there are only a few protein tumor markers that are associated with a particular cancer and are clinically useful; most types of cancer have not been linked to an increase in the levels of a particular protein tumor marker (Source). Furthermore, these types of tests have a poor sensitivity and specificity, meaning that these markers may be elevated in people that do not have cancer and that not every person with a particular type of cancer will have an elevated level of the corresponding tumor marker (Source). Taking the PSA test as an example, which measures the amount of PSA in blood and is used to screen for prostate cancer, approximately 66% of men with increased levels of PSA do not have prostate cancer, whereas over 15% of the men with normal levels of PSA may have prostate cancer (Source).
The isolation and analysis of CTCs is a relatively new practice, and physicians are starting to recognize all its potential benefits. Most of the current CTCs technologies, including the CellSearch® System, which is considered the gold standard, rely on the existence of specific proteins on the tumor cell membrane in order to capture them. However, CTCs are incredibly heterogeneous; when entering the bloodstream, they undergo a biological process that downregulates these proteins, limiting the efficiency with which these cells are captured and thereby losing valuable information (Source, Source). Our technology changes the norm by isolating CTCs irrespective of the proteins expressed in their membranes, allowing us to capture tumor cells that other technologies simply can’t.
*Images used in this photo are in the prototype phase, CytoCatch is not currently available on the market.
Our Vision
Maximum Number of Shares Offered subject to adjustment for bonus shares
04.07.22
The campaign is 6 hours away from finishing. Thank you for your support and your feedback during our SE campaign.
If you reserved during the TTW stage this is your last chance to confirm your investment to get your bonus share, and to all the people interested in investing, here are some of the reasons why we think you should.
CTCs are a very powerful biomarker; their analysis enables the study of cancer cells derived from tumors in a non-invasive way, allowing DNA, RNA, and protein-based molecular profiling, which will generate valuable information to help physicians make information-driven decisions concerning cancer diagnosis and treatment’s response assessment.
Delee is backed by Y Combinator, StartX, and Emles Venture Partners.
The founders have a scientific background and more than 10 years of experience developing scientific instrumentation.
Our company has a multidisciplinary team of scientists and engineers, and has a strong advisory board composed of people with experience in the scientific and clinical fields,
Delee will start commercializing its technology as a research use only device by Q4 of this year, for which FDA clearance is not required.
To date, pre-orders worth a potential value of over $2.5M have been secured from 11 research centers of various hospitals, including the Stanford University Medical Center.
The TAM for the use of CTCs in clinical applications is calculated at over $543B.
We are running a clinical study to validate the use of our technology in applications related to prostate cancer. Furthermore, we have three patent pending applications that protect different aspects of our technology, and published peer-reviewed articles in Nature Scientific Reports.
Thanks to all investors for believing in our vision and for making it a reality.
Delee Team 💙
04.06.22
The campaign is 12 hours away from finishing. Thank you for your support and your feedback during our SE campaign.
If you reserved during the TTW stage this is your last chance to confirm your investment to get your bonus share, and to all the people interested in investing, here are some of the reasons why we think you should.
CTCs are a very powerful biomarker; their analysis enables the study of cancer cells derived from tumors in a non-invasive way, allowing DNA, RNA, and protein-based molecular profiling, which will generate valuable information to help physicians make information-driven decisions concerning cancer diagnosis and treatment’s response assessment.
Delee is backed by Y Combinator, StartX, and Emles Venture Partners.
The founders have a scientific background and more than 10 years of experience developing scientific instrumentation.
Our company has a multidisciplinary team of scientists and engineers, and has a strong advisory board composed of people with experience in the scientific and clinical fields,
Delee will start commercializing its technology as a research use only device by Q4 of this year, for which FDA clearance is not required.
To date, pre-orders worth a potential value of over $2.5M have been secured from 11 research centers of various hospitals, including the Stanford University Medical Center.
The TAM for the use of CTCs in clinical applications is calculated at over $543B.
We are running a clinical study to validate the use of our technology in applications related to prostate cancer. Furthermore, we have three patent pending applications that protect different aspects of our technology, and published peer-reviewed articles in Nature Scientific Reports.
Thanks to all investors for believing in our vision and for making it a reality.
Delee Team 💙
04.06.22
The campaign is less than 24 hours away from finishing. Thank you for your support and your feedback during our SE campaign.
If you reserved during the TTW stage this is your last chance to confirm your investment to get your bonus share, and to all the people interested in investing, here are some of the reasons why we think you should.
CTCs are a very powerful biomarker; their analysis enables the study of cancer cells derived from tumors in a non-invasive way, allowing DNA, RNA, and protein-based molecular profiling, which will generate valuable information to help physicians make information-driven decisions concerning cancer diagnosis and treatment’s response assessment.
Delee is backed by Y Combinator, StartX, and Emles Venture Partners.
The founders have a scientific background and more than 10 years of experience developing scientific instrumentation.
Our company has a multidisciplinary team of scientists and engineers, and has a strong advisory board composed of people with experience in the scientific and clinical fields,
Delee will start commercializing its technology as a research use only device by Q4 of this year, for which FDA clearance is not required.
To date, pre-orders worth a potential value of over $2.5M have been secured from 11 research centers of various hospitals, including the Stanford University Medical Center.
The TAM for the use of CTCs in clinical applications is calculated at over $543B.
We are running a clinical study to validate the use of our technology in applications related to prostate cancer. Furthermore, we have three patent pending applications that protect different aspects of our technology, and published peer-reviewed articles in Nature Scientific Reports.
Thanks to all investors for believing in our vision and for making it a reality.
Delee Team 💙
04.05.22
We’re close to the end of our campaign. From everyone working at Delee we would like to say that your support has been very important to all of us.
If you reserved during the TTW stage there is still time to confirm your investment to get your bonus share, and to all the people interested in investing, here are some of the reasons why we think you should.
CTCs are a very powerful biomarker; their analysis enables the study of cancer cells derived from tumors in a non-invasive way, allowing DNA, RNA, and protein-based molecular profiling, which will generate valuable information to help physicians make information-driven decisions concerning cancer diagnosis and treatment’s response assessment.
Delee is backed by Y Combinator, StartX, and Emles Venture Partners.
The founders have a scientific background and more than 10 years of experience developing scientific instrumentation.
Our company has a multidisciplinary team of scientists and engineers, and has a strong advisory board composed of people with experience in the scientific and clinical fields,
Delee will start commercializing its technology as a research use only device by Q4 of this year, for which FDA clearance is not required.
To date, pre-orders worth a potential value of over $2.5M have been secured from 11 research centers of various hospitals, including the Stanford University Medical Center.
The TAM for the use of CTCs in clinical applications is calculated at over $543B.
We are running a clinical study to validate the use of our technology in applications related to prostate cancer. Furthermore, we have three patent pending applications that protect different aspects of our technology, and published peer-reviewed articles in Nature Scientific Reports.
Thanks to all investors for believing in our vision and for making it a reality.
Delee Team 💙
04.04.22
Hello everyone!
Circulating tumor cells (CTCs) have attracted a significant amount of attention for their potential use as a blood-based biomarker to help physicians make information-driven decisions concerning cancer diagnosis and treatment’s response assessment. The analysis of these cells will enable the study of cancer cells derived from tumors in a non-invasive way, allowing DNA, RNA, and protein-based molecular profiling. However, their heterogeneity and extremely low concentration in comparison to the other cellular components of blood, about 1–10 CTCs per billion blood cells, makes their capture extremely challenging… until now.
We have developed the CytoCatch™ isolation platform, which automatically performs the necessary steps to prepare and process the sample, capturing the contained CTCs. The CytoCatch™ isolation platform has the sensitivity to isolate a single CTC from a background of 50 billion blood cells, isolating these malignant cells by leveraging the difference in size and deformability between CTCs and blood cells. Once captured, the CytoCatch™ isolation platform executes an automated protocol to stain the collected cells with fluorescent antibodies for their further analysis, allowing the identification of the patient’s tumor biological characteristics. The fact that all these processes are fully automated increases the reliability and reproducibility of the assay by preventing human error and cell loss due to manual steps. Furthermore, the CytoCatch™ isolation platform is compatible with traditional molecular biology techniques and next generation sequencing technologies, enabling the performance of molecular analyses to assess the genetic characteristics of the captured CTCs.
We are so excited because we are only a few months away from being able to start commercializing our technology as a research use only device, for its use in research centers and pharma companies.
We want to take this opportunity to remind you that there are less than 48 hours left until Delee’s campaign ends. For those who reserved shares during the TTW stage, you only have this period of time to confirm your investment and receive your 10% bonus shares. If you haven't made an investment yet, and you’re interested, there’s still time to do so.
Thanks to everyone who supported us by becoming investors in Delee.
Delee Team 💙
04.03.22
We’re almost reaching the end of our campaign. It has been heartwarming to know that many people believe in what we’re doing and most importantly that they believe in us.
For the people that reserved but did not confirm their investment remember that you still have this period of time to confirm and receive your bonus shares.
For our followers still on the fence about investing here is why we think you should invest in us
CTCs are a very powerful biomarker; their analysis enables the study of cancer cells derived from tumors in a non-invasive way, allowing DNA, RNA, and protein-based molecular profiling, which will generate valuable information to help physicians make information-driven decisions concerning cancer diagnosis and treatment’s response assessment.
Delee is backed by Y Combinator, StartX, and Emles Venture Partners.
The founders have a scientific background and more than 10 years of experience developing scientific instrumentation.
Our company has a multidisciplinary team of scientists and engineers, and has a strong advisory board composed of people with experience in the scientific and clinical fields,
Delee will start commercializing its technology as a research use only device by Q4 of this year, for which FDA clearance is not required.
To date, pre-orders worth a potential value of over $2.5M have been secured from 11 research centers of various hospitals, including the Stanford University Medical Center.
The TAM for the use of CTCs in clinical applications is calculated at over $543B.
We are running a clinical study to validate the use of our technology in applications related to prostate cancer. Furthermore, we have three patent pending applications that protect different aspects of our technology, and published peer-reviewed articles in Nature Scientific Reports.
Thanks to everyone who supported us by becoming investors in Delee.
Delee Team 💙
04.02.22
We’re almost reaching the end of our campaign. It has been heartwarming to know that many people believe in what we’re doing and most importantly that they believe in us.
For the people that reserved but did not confirm their investment remember that you still have this period of time to confirm and receive your bonus shares.
For our followers still on the fence about investing here is why we think you should invest in us
CTCs are a very powerful biomarker; their analysis enables the study of cancer cells derived from tumors in a non-invasive way, allowing DNA, RNA, and protein-based molecular profiling, which will generate valuable information to help physicians make information-driven decisions concerning cancer diagnosis and treatment’s response assessment.
Delee is backed by Y Combinator, StartX, and Emles Venture Partners.
The founders have a scientific background and more than 10 years of experience developing scientific instrumentation.
Our company has a multidisciplinary team of scientists and engineers, and has a strong advisory board composed of people with experience in the scientific and clinical fields,
Delee will start commercializing its technology as a research use only device by Q4 of this year, for which FDA clearance is not required.
To date, pre-orders worth a potential value of over $2.5M have been secured from 11 research centers of various hospitals, including the Stanford University Medical Center.
The TAM for the use of CTCs in clinical applications is calculated at over $543B.
We are running a clinical study to validate the use of our technology in applications related to prostate cancer. Furthermore, we have three patent pending applications that protect different aspects of our technology, and published peer-reviewed articles in Nature Scientific Reports.
Thanks to everyone who supported us by becoming investors in Delee.
Delee Team 💙
04.01.22
Hello everyone!
As you know, our technology is composed of two devices, the CytoCatch™ isolation platform, which processes the sample capturing the contained CTCs, and the CytoCatch™ imaging system, which performs the analysis of the captured cells. In this update we want to talk about some of the characteristics that make the CytoCatch™ imaging system an ideal platform for CTC analysis.
Once the sample has been processed, the substrate where the CTCs are captured is placed in the CytoCatch™ imaging system to enumerate CTCs and identify specific biological characteristics that give information to physicians about treatment selection and therapy response assessment. The CytoCatch™ imaging system has very unique characteristics that allow the complete mapping of the substrate area where the CTCs were captured, as shown in the video. This mapping is performed at different focal planes to ensure that all the cells are in focus, increasing the reliability of the analysis. Furthermore, the CytoCatch™ imaging system allows the fluorescence-based identification of up to 6 different markers in the captured cells, which gives the flexibility to create specific panels for a wide variety of cancers, providing valuable information to physicians regarding the identification of possible markers that serve as targets for targeted therapies. Finally, the CytoCatch™ imaging system has a powerful built-in AI that enumerates the captured CTCs and categorizes them based on their biological characteristics, thereby eliminating the subjective interpretation of operators and increasing the reproducibility of analysis, while decreasing the time needed to manually enumerate the CTCs captured.
We are so excited because we are only a few months away from being able to start commercializing our technology as a research use only device, for its use in research centers and pharma companies.
We want to take this opportunity to remind you that there are only 5 days left until Delee’s campaign ends. For those who reserved shares during the TTW stage, you only have this period of time to confirm your investment and receive your 10% bonus shares. If you haven't made an investment yet, and you’re interested, there’s still time to do so.
Thanks to everyone who supported us by becoming investors in Delee.
Delee Team 💙
04.01.22
We are thrilled to announce that our campaign has passed $300k in investments, we are so happy to reach another milestone!
What we have accomplished has only been possible thanks to everyone who has joined our mission of revolutionizing cancer blood tests.
We are on the final days of our campaign, for those who reserved shares during the TTW stage, these are the last days you have to confirm your investment and receive your 10% bonus shares.
And if you haven't invested yet, you still have time to do so.
Delee Team 💙
03.31.22
Hello everyone!
The final week of our campaign has started. To everyone that has supported us and has become an investor we would like to thank you for allowing us to continue our endeavor of helping people with cancer detection and treatment.
For those who reserved shares during the TTW stage, you still have this next week to confirm your investment and receive your 10% bonus shares.
And if you haven't invested yet, and you’re interested, you still have time to do so.
Thank you!
Delee Team 💙
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Lanelle Schultz
4 years ago
Hello Team Delee, Just did my reserve and am super excited. I participated on Republic as well. Yesterday I was at the doctor and showed him your website he was blown away. Happy to be on this ride with you for part 2! Lanelle
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